Research Laboratory of Prediabetes and Metabolic Disorders

Head of Laboratory: Alina Babenko, MD, DSc.

Major tasks

To predict the risks of carbohydrate metabolism disorders in patients with obesity and metabolic syndrome based on genetic and phenotypic predictors.
To develop personalized weight loss approaches; to identify predictors of response to various weight loss methods both through lifestyle changes and medication.

Focus area

The Laboratory focuses on predicting the manifestation of carbohydrate metabolism disorders by analyzing the genetic and phenotypic data of deeply profiled patient cohorts.

Specialists

Alina Babenko, MD, DSc, Head of Laboratory
Yulia Kononova, Researcher
Tatiana Golikova (Alekseenko), Junior Researcher
Georgy Matveev, Junior Researcher
Maria Firuleva, Research Assistant
Alexander Loboda, Research Assistant

Newly developed and implemented technologies

"Automated information system for antidiabetic therapy selection" to support decision-making by a general practitioner (endocrinologist) when choosing therapy for 2nd line diabetes (State Registration Certificate No. 2020615687).

Scales for predicting the response to weight-loss therapy with Liraglutide and Sibutramine have been developed, and their effectiveness is being assessed.

Major publications

Lebedev D. A., Lyasnikova E. A., Vasilyeva E. Yu , Babenko A. Yu and Shlyakhto E. V. Type 2 Diabetes Mellitus and Chronic Heart Failure with Midrange and Preserved Ejection Fraction: A Focus on Serum Biomarkers of Fibrosis. Journal of Diabetes Research Volume 2020, Article ID 6976153, 9 pages https://doi.org/10.1155/2020/6976153 ИФ -3,4, Q2 SJR 0,99 Scopus
Kononova Yu. A., Fedostsova D. A., Dvoretskaya E.A., Papayan G. V., Babenko A. Yu., Grineva E. N. Skin autofluorescence measured with fluorescent spectrometry and blood lipids level in diabetic patients. Proceedings of SPIE. 2020. Vol. 11362. pp. 113620E http://dx.doi.org/10.1117/12.2555940 SJR 0,27
Derevitskii I. V., Matveev G. A., Vasilieva E. Yu., Babenko A. Yu., Lutsenko A.E. Predictive Modelling of Weight -Loss-Therapy Results for Patients with Obesity. Procedia Computer Science 2020 (Scopus,) SJR 034
Babenko A. Yu., Savitskaya D. A., Kononova Yu. A., Trofimova A. Yu., Simanenkova A. V., Vasileva E. Yu., Shlyakhto E. V. Predictors of effectiveness of glucagon-like peptide-1 receptor agonist therapy in patients with type 2 diabetes and obesity Journal of Diabetes Research. 2019. Т. 2019. С. 1365162. IF 3,04 https://www.hindawi.com/journals/jdr/2019/1365162/
Babenko A. Y., Mosikian A. A., Lebedev D. L., Khrabrova E. A., Shlyakhto E. V. Mental state, psychoemotional status, quality of life and treatment compliance in patients with type 2 diabetes mellitus. Journal of Comparative Effectiveness Research. 2019. Т. 8. № 2. С. 113-120. IF 2,268 https://www.futuremedicine.com/doi/full/10.2217/cer-2018-0105?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed&
Kononova Yu., Arkhipova A., Papayan G., Khodzitsky M., Babenko A., Grineva E. Measurement of skin autofluorescence by fluorescent spectrometry for diabetes diagnostics and control. Proc. SPIE 10685, Biophotonics: Photonic Solutions for Better Health Care VI, 106852N (17 May 2018); doi: 10.1117/12.2307250 (ИФ-0,56 Scopus)
Zhang T., Demchenko P. S., Khodzitskiy M. K., Kononova Yu. A., Babenko A.Y., Grineva E.N. The influence of bilirubin and creatinine on the refractive index of whole blood in terahertz frequency range: a qualitative analysis. Proceedings of SPIE. 2018; 10820: 108200. doi: 10.1117/12.2500855 (ИФ 0,56, Scopus)

Contacts

Alina Babenko, Head of the Laboratory
e-mail: babenko_ayu@almazovcentre.ru