Research Laboratory of Excessive Calcification Diseases

Head of Laboratory: Dmitry Tolpygin, MD, PhD.

Major tasks

  • To organize and carry out preclinical and clinical studies in the field of congenital and acquired diseases of the aorta and aortic valve.

  • To provide Information support and coordinate the interaction of the Centre’s research teams with users of research products in order to actively promote the Centre’s developments in the market of intellectual services, high technologies and search for investors.

Focus areas

  • Molecular and genetic studies of the mechanisms underlying the development of congenital and acquired diseases of the aorta and aortic valve.

  • Systematizing, improving and developing new methods for diagnosing the diseases of the aorta and aortic valve.

  • Developing and introducing into clinical practice new technologies and approaches to surgical, transcatheter and hybrid treatment of diseases of the aorta and aortic valve.

  • Carrying out a long-term follow-up of patients after various surgical procedures on the aorta and aortic valve as well as those receiving medical treatment.


Searching for new directions of targeted therapy for congenital and acquired diseases with excessive calcification.


1. Research Group of Molecular Mechanisms of Calcification

  • Anna Malashicheva, DSc in Biology, Head of Group 
  • Arseny Lobov, PhD in Biology, Researcher
  • Nadezhda Boyarskaya, Junior Researcher 
  • Anastasia Shishkova, Junior Researcher
  • Pavel Dokshin, Junior Researcher
  • Olga Kachanova, Research Assistant 

2. Biological Modelling Research Group

  • Pavel Kvindt, Junior Researcher 

Major publications

Patents and inventions


Dmitry Tolpygin, Head of Laboratory