Research Laboratory of Excessive Calcification Diseases

Head of the Laboratory — Vladimir Uspensky.

Specialists of the Laboratory

Junior Researcher Egor Karev
Junior Researcher Alexander Pischugin
Junior Researcher Alexey Filippov

Structure

1. Research Group of Molecular Mechanisms of Calcification

Head of the Group — Anna Malashicheva
Junior Researcher Pavel Dokshin
Research Assistant Nadezhda Boyarskaya

2. Biological Modelling Research Group

Major publications

Kozyrev I., Dokshin P., Kostina A, et al. Dysregulation of Notch signaling in cardiac mesenchymal cells of patients with tetralogy of Fallot. Pediatr Res. 2020;(November 2019):1-10. doi:10.1038/s41390-020-0760-6 IF 2,7, Q1
Malashicheva A., A. Kostina, A. Kostareva, O. Irtyuga, M. Gordeev and V. Uspensky (2020). “Notch signaling in the pathogenesis of thoracic aortic aneurysms: A bridge between embryonic and adult states.” Biochim Biophys Acta Mol Basis Dis 1866(3): 165631. https://doi.org/10.1016/j.bbadis.2019.165631 IF 4,3 Q1
Aquila G., Kostina A., Vieceli Dalla Sega F., Shlyakhto E., Kostareva A., Marracino L., Ferrari R., Rizzo P., Malaschicheva A. 2019 The Notch pathway: a novel therapeutic target for cardiovascular diseases? Expert Opin Ther Targets 23:695–710. https://doi.org/10.1080/14728222.2019.1641198 IF 4,6, Q1
Semenova, D., M. Bogdanova, A. Kostina, A. Golovkin, A. Kostareva and A. Malashicheva (2020). “Dose-dependent mechanism of Notch action in promoting osteogenic differentiation of mesenchymal stem cells.” Cell Tissue Res 379(1): 169–179. DOI: 10.1007/s00441-019–03130 7 IF 3,4, Q1
Perepelina K., Klauzen P., Kostareva A., Malashicheva A. Tissue-Specific Influence of Lamin A Mutations on Notch Signaling and Osteogenic Phenotype of Primary Human Mesenchymal Cells. Cells. 2019 Mar 21;8(3). doi: 10.3390/cells8030266 IF 5,6 Q1
Kostina A., Shishkova A., Ignatieva E., Irtyuga O., Bogdanova M., Levchuk K., Golovkin A., Zhiduleva E., Uspenskiy V., Moiseeva O., Faggian G., Vaage J., Kostareva A., Rutkovskiy A., Malashicheva A. Different Notch signaling in cells from calcified bicuspid and tricuspid aortic valves. J Mol Cell Cardiol. 2018 114:211–219. doi: 10.1016/j.yjmcc.2017.11.009. IF 5,68 Q1
Ignatieva E., Kostina D., Irtyuga O., Uspensky V., Golovkin A., Gavriliuk N., Moiseeva O., Kostareva A., Malashicheva A.. Mechanisms of Smooth Muscle Cell Differentiation Are Distinctly Altered in Thoracic Aortic Aneurysms Associated with Bicuspid or Tricuspid Aortic Valves. Front Physiol. 2017 Jul 25;8:53 https://www.frontiersin.org/articles/10.3389/fphys.2017.00536/full IF 4,1 Q1
Rutkovskiy A., Malashicheva A., Sullivan G., Bogdanova M., Kostareva A., Stensløkken KO., Fiane A., Vaage J. Valve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcification. J Am Heart Assoc. 2017 Sep 14;6(9). pii: e006339. doi: 10.1161/JAHA.117.006339. IF 5,1 Q1
Kostina D., Zverev D., Gordeev M., Ignatieva E., Voronkina I., Kostareva A., Malashicheva A. Aortic graft at coronary artery bypass surgery as a source of human aortic smooth muscle cells. Cell Transplant. 2017 Oct;26(10):1663–1668. doi: 10.1177/0963689717721226. IF 3,2 Q1
Kostina A. S., Uspensky V. Е., Irtyuga O. B., Ignatieva E. V., Freylikhman O., Gavriliuk N. D., Moiseeva O. M., Zhuk S., Tomilin A., Kostareva А. А., Malashicheva A. B. Notch-dependent EMT is attenuated in patients with aortic aneurysm and bicuspid aortic valve. Biochim Biophys Acta. 2016 Apr;1862(4):733–40 http://www-ncbi-nlm-nih-gov.proxy.kib.ki.se/pubmed/26876948 IF 5,2 Q1

Contacts

Vladimir Uspensky, Head of the Laboratory
e-mail: uspenskiy_ve@almazovcentre.ru