World-Class Research Centre
for Personalized Medicine
2 Akkuratova street, St. Petersburg 197341
Risk factors for polygenic diseases will be identified using a genome-wide association study focusing on the association between genomic variants and phenotypic traits (GWAS).
A reference database of genomic data for the Russian population will be created (within the Leningrad region).
Both the spectrum of genetic determinants associated with an altered pharmacological response to the listed classes of drugs and a list of clinical conditions and factors affecting the prediction of the efficacy and safety of standard therapy will be analyzed and identified.
A model will be built for personalized diagnosis, prognosis and management of patients with metabolic disorders, obesity and type 2 diabetes.
Based on the obtained lipidomic analysis data, personalized cardiovascular risk prediction programmes will be developed to determine the list of clinical characteristics indicative of an unfavorable prognosis upon admission of a patient with acute coronary syndrome that would predetermine the choice of a more aggressive therapeutic and interventional strategy.