Research Centre of Personalized Oncology

Head of the Centre — Konstantin Samochernykh.

Structure

Research Laboratory of Neuroendocrine Tumors

Research Group of Theranostics

Research Department of Immuno-Oncology

Research Department of Translational Oncology

Major publications

Genetic polymorphisms associated with rheumatoid arthritis development and antirheumatic therapy response. Mikhaylenko D. S., Nemtsova M. V., Bure I. V., Deviatkin A.A., Zamyatnin A.A. International Journal of Molecular Sciences, 2020, 21(14), р. 1-17.
Antihypertensive effect of amlodipine in co-administration with omeprazole in patients with hypertension and acid-related disorders: Cytochrome P450-associated aspects. Dorofeeva M. N., Shikh E. V., Sizova Z. M., Grishina E. A., Sychev D. A. Pharmacogenomics and Personalized Medicine, 2019, 12, р. 329-339
Roles of e-cadherin and noncoding rnas in the epithelial–mesenchymal transition and progression in gastric cancer. Bure I. V., Nemtsova M. V., Zaletaev D. V. International Journal of Molecular Sciences, 2019, 20(12), 2870 Q1
Epigenetic changes in the pathogenesis of rheumatoid arthritis. Nemtsova M. V., Zaletaev D. V., Bure I.V., Lukashev A. N., Zamyatnin A. A. Frontiers in Genetics, 2019, 10(JUN), 570 Q1
Antihypertensive effect of amlodipine in co-administration with omeprazole in patients with hypertension and acid-related disorders: Cytochrome P450-associated aspects. Dorofeeva M. N., Shikh E. V., Sizova Z. M., Grishina E. A., Sychev D. A. Pharmacogenomics and Personalized Medicine, 2019, 12, р. 329-339
Long noncoding RNA HOTAIR is upregulated in an aggressive subgroup of gastrointestinal stromal tumors (GIST) and mediates the establishment of gene-specific DNA methylation patterns. Bure I., Geer S., Knopf J., Haller F., Moskalev E.A. Genes Chromosomes and Cancer, 2018, 57(11), с. 584-597
Neumann H. P. H., Tsoy U., Bancos I., Amodru V., Walz M. K., Tirosh A., et al; International Bilateral-Pheochromocytoma-Registry Group (Grineva E.N. among the International Bilateral-Pheochromocytoma-Registry Group). Comparison of Pheochromocytoma-Specific Morbidity and Mortality among Adults with Bilateral Pheochromocytomas Undergoing Total Adrenalectomy vs Cortical-Sparing Adrenalectomy.//JAMA Network Open. - 2019. Aug 2;2(8):e198898. DOI: 10.1001/jamanetworkopen.2019.8898
Criteria for the definition of Pituitary Tumor Centers of Excellence (PTCOE): A Pituitary Society Statement. Casanueva F. F., Barkan A. L., Buchfelder M., Klibanski A., Laws E. R., Loeffler J. S., Melmed S., Mortini P., Wass J., Giustina A.; Pituitary Society, Expert Group on Pituitary Tumors.Pituitary. 2017 Oct;20(5):489-498. doi: 10.1007/s11102-017-0838-2.
Shuvalov O., Kizenko A., Petukhov A., Aksenov N., Fedorova O., Vorobev M., Daks A., Barlev N. Cancer-testis antigens, semenogelins 1 and 2, exhibit different anti-proliferative effects on human lungadenocarcinoma cells. Cell Death Discov. 2020;6:108. doi: 10.1038/s41420-020-00336-5. eCollection 2020. PubMed PMID: 33101710; PubMed Central PMCID: PMC7581521.
Fedorova O., Daks A., Shuvalov O., Kizenko A., Petukhov A., Gnennaya Y., Barlev N. Attenuation of p53 mutant as an approach for treatment Her2-positive cancer. Cell Death Discov. 2020;6:100. doi: 10.1038/s41420-020-00337-4. eCollection 2020. Review. PubMed PMID: 33083021; PubMed Central PMCID: PMC7548004.
Vasileva E., Shuvalov O., Petukhov A., Fedorova O., Daks A., Nader R., Barlev N. KMT Set7/9 is a new regulator of Sam68 STAR-protein. Biochem Biophys Res Commun. 2020 May 14;525(4):1018-1024. doi: 10.1016/j.bbrc.2020.03.017. Epub 2020 Mar 13. PubMed PMID: 32178870.
Titov A., Valiullina A., Zmievskaya E., Zaikova E., Petukhov A., Miftakhova R., Bulatov E., Rizvanov A. Advancing CAR T-Cell Therapy for Solid Tumors: Lessons Learned from Lymphoma Treatment. Cancers (Basel). 2020 Jan 3;12(1). doi: 10.3390/cancers12010125. Review. PubMed PMID: 31947775; PubMed Central PMCID: PMC7016531.
Efimova O. A., Koltsova A. S., Krapivin M. I., Tikhonov A. V., Pendina A. A. Environmental Epigenetics and Genome Flexibility: Focus on 5-Hydroxymethylcytosine. International Journal of Molecular Sciences. 2020;21(9):3223.
Sharma N., Fonin A. V., Shpironok O. G., Silonov S. A., Turoverov K. K., Uversky V. N. Folding perspectives of an intrinsically disordered transactivation domain and its single mutation breaking the folding propensity. Int. J. Biomacromol, 2019.
Shevtsov M., Stangl S., Nikolaev B., Yakovleva L., Marchenko Y., Tagaeva R., Sievert W., Pitkin E., Mazur A., Toltoy P., Galibin O., Ryzhov V., Steiger K., Smirnov O., Khachatryan W., Chester K., Multhoff G. Granzyme B functionalized nanoparticles targeting membrane Hsp70-positive tumors for multimodal cancer theranostics. Small. 2019; 15(13):e1900205. WoS IF = 10.856, Q1
Goryaynov S. A., Okhlopkov V. A., Golbin D. A., Chernyshov K. A., Svistov D. V., Martynov B. V., Kim A. V., Byvaltsev V. A., Pavlova G. V., Batalov A., Konovalov N. A., Zelenkov P. V., Loschenov V. B., Potapov A. A. Fluorescence Diagnosis in Neurooncology: Retrospective Analysis of 653 Cases. Front Oncol. 2019;9:830. WoS IF = 4.848, Q1
Shevtsov M., Sato H., Multhoff G., Shibata A. Novel approaches to improve the efficacy of immuno-radiotherapy. Frontiers in Oncology. 2019;9:156. WoS IF = 4.25, Q1
Shevtsov M., Pitkin E., Ischenko A., Stangl S., Khachatryan W., Galibin O., Edmond S., Lobinger D., Multhoff G. Ex vivo Hsp70-activated NK cells in combination with PD-1 inhibition significantly increase overall survival in preclinical models of glioblastoma and lung cancer. Frontiers in Immunology. 2019;10:454. WoS IF = 4.716, Q1
Stangl S., Tei L., De-Rose F., Reder S., Martinelli J., Sievert W., Shevtsov M., Öllinger R., Rad R., Schwaiger M., Alessandria C.D., Multhoff G. Preclinical evaluation of the Hsp70 peptide tracer TPP-PEG24-DFO[89Zr] for tumor-specific PET/CT imaging. Cancer Research. 2018;78(21):6268-628. WoS IF = 8.378, Q1
Shevtsov M., Nikolaev B., Marchenko Y., Yakovleva L., Skvorzov N., Mazur A., Tolstoy P., Ryzhov V., Multhoff G. Targeting experimental glioblastoma with chitosan-based superparamagnetic iron oxide nanoparticles (CS-DX-SPIONs). International Journal of Nanomedicine. 2018;13:1471-1482. WoS IF = 4.471, Q1
Stangl S., Tontcheva N., Sievert W., Shevtsov M., Niu M., Schmid T. E., Pigorsch S., Combs S. E., Haller B., Balermpas P., Rödel F., Rödel C., Fokas E., Krause M., Linge A., Lohhaus F., Baumann M., Tinhofer I., Budach V., Stuschke M., Grosu A.L., Abdollahi A., Debus J., Belka C., Maihöfer C., Mönnich D., Zips D., Multhoff G. Heat shock protein 70 and tumor-infiltrating NK cells as prognostic indicators for patients with squamous cell carcinoma of the head and neck after radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG). International Journal of Cancer. 2018;142(9):1911-1925. WoS IF = 4.982, Q1
Shevtsov M. A., Parr M. A., Ryzhov V. A., Zemtsova E. G., Ponomareva A. N., Smirnov V. M., Multhoff G. Zero-valent Fe confined mesoporous silica nanoparticles (Fe(0)@MCM-41) for targeting experimental orthotopic glioma in rats. Scientific Reports. 2016;6:29247. WoS IF = 4.011, Q1
Marina V. Filimonova, Victoria M. Makarchuk, Ljudmila I. Shevchenko, Alina S. Saburova, Valentina I. Surinova, Olga S. Izmestieva, Anatoly A. Lychagin, Vyacheslav O. Saburov, Petr V. Shegay, Andrey D. Kaprin, Sergey A. Ivanov, Alexander S. Filimonov / Radioprotective Activity of the Nitric Oxide Synthases Inhibitor T1023. Toxicological and Biochemical Properties, Cardiovascular and Radioprotective Effects // Radiation Research, 2020, принята к публикации 3.08.20.
Saburova A. S., Filimonova M. V., Yuzhakov V. V., Shevchenko L. I., Yakovleva N. D., Bandurko L. N., Koretskaya A. E., Fomina N. K., Saburov V. O., Filimonov A. S. / The influence of nitric oxide synthases inhibitor Т1023 on the development of radiation pneumofibrosis in rats // Radiatsionnaya Gygiena, 2020, 13(1), р. 60-67 DOI: 10.21514/1998-426Х-2020-13-1-60-67
Alexeev A. A., Nurieva E. V., Trofimova T. P., Chesnakova E. A., Grishin Y. K., Lyssenko K. A., Filimonova M. V., Zefirova O. N. / Bicyclic bridged isothioureas: synthesis and evaluation of activity in a model of lipopolysaccharide-induced septic shock // Mendeleev Communications, 2019, 29(1), p. 14-16 DOI: 10.1016/j.mencom.2019.01.003
Nurieva E. V., Trofimova T. P., Alexeev A. A., Proshin A. N., Chesnakova E. A. d., Grishin Y. K., Lyssenko K. A., Filimonova M. V., Bachurin S. O., Zefirova O. N. / Synthesis and antihypotensive properties of 2-amino-2-thiazoline analogues with enhanced lipophilicity // Mendeleev Communications, 2018, 28(4), с. 390-392 DOI: 10.1016/j.mencom.2018.07.016
Filimonova M. V., Podosinnikova T. S., Samsonova A. S., Makarchuk V. M., Shevchenko L. I., Filimonov A. S. / Comparison of Antitumor Effects of Combined and Separate Treatment with NO Synthase Inhibitor T1023 and PDK1 Inhibitor Dichloroacetate // Bulletin of Experimental Biology and Medicine, 2019, 168(1), p. 92-94 DOI: 10.1007/s10517-019-04655-1
Efimenko I. A., Filimonova M. V., Churakov A. V., Ivanova N. A., Erofeeva O. S., Samsonova A. S., Podosinnikova T. S., Filimonov A. S. / First Polynuclear Palladium Compounds [(C5H12NO)(PdCl3)]n and [(C10H16NO)2(Pd2Cl6)] with High Antitumor and Radioprotective Activity // Russian Journal of Coordination Chemistry/Koordinatsionnaya Khimiya, 2020, 46(5), р. 339-349 DOI: 10.1134 / S1070328420040028
Filimonova M. V., Shevchenko L. I., Makarchuk V. M., Chesnakova E. A., Shevchuk A. S., Filimonov A. S., Kryzhanovskii S. A. / Vasopressor Properties of No Synthase Inhibitor T1059. Part II. Hemodynamic Effects on Hypovolemic Disorders // Pharmaceutical Chemistry Journal, 2020, 53(12), р.1113-1117 DOI: 10.1007/s11094-020-02132-y
Makarchuk V. M., Filimonova M. V., Filimonov A. S., Shevchenko L. I., Izmestieva O. S., Saburova A. S. / Lactatemia as a possible pharmacological marker of NOS-inhibitor T1023 induced radioresistance / Radiation and Risk, 2020, 29(1), р. 45-56 DOI: 10.21870 / 0131-3878-2020-29-1-45-56
Filimonova M. V., Evstratova E. S., Makarchuk V. M., Shevchenko L. I., Filimonov A. S., Petin V. G. / Involvement of Recovery Processes in the Effects of Radioprotectors at the Cellular and Organismal Levels // Biology Bulletin, 2019, 46(12),p. 1619-1624 DOI: 10.1134/S1062359019120033
Filimonova M. V., Shevchenko L. I., Makarchuk V. M., Chesnakova E. A., Surinova V. I., Shevchuk A. S., Filimonov A. S., Kryzhanovskii S. A., Shevchenko T. F., Bugrova A. E., Kalamkarov G. R. / Vasopressor Properties of Nitric Oxide Synthase Inhibitor T1059. Part I: Synthesis, Toxicity, NOS-Inhibition Activity, and Hemodynamic Effects Under Normotensive Conditions // Pharmaceutical Chemistry Journal, 2018, 52(4), с. 294-298 DOI: 10.1007/s11094-018-1809-2
Filimonova M. V., Samsonova A. S., Korneeva T. S., Shevchenko L. I., Filimonov A. S. / Study of the ability of a new nitric oxide synthase inhibitor INOS1 to selectively protect the normal tissue in the Ehrlich carcinoma radiotherapy model // Radiation and Risk, 2018, 27(2), с. 37-45 DOI: 10.21870 / 0131-3878-2018-27-2-37-45
Filimonova M. V., Samsonova A. S., Korneeva T. S., Shevchenko L. I., Saburov V. O., Filimonov A. S. / The radioprotective effects of nitric oxide synthase inhibitor T1023 on normal and malignant tissues // Radiation and Risk, 2018, 27(2), с. 37-45 DOI: 10.21870 / 0131-3878-2018-27-4-155-169
Simakova M. A., Karpova D. V., Marukyan N. V. et. al Dual-energy computed tomography-angiography in the evaluation and management of significant multiple pulmonary vein stenoses following atrial fibrillation ablation Pulmonary Circulation 2020; 10(4) 1–3 DOI: 10.1177/2045894020969499
Antuganov D., Zykov M., Timofeev V. et al.
Copper‐mediated radiofluorination of aryl pinacolboronate esters: a straightforward protocol by using pyridinium sulfonates.
European journal of organic chemistry. 2019; 5: 918–922. DOI:10.1002/ejoc.201801514.
Antuganov D., Timofeev V., Timofeeva K. et al.
Evaluation of protic ionic liquids based on triethanolammonium and Tris (hydroxymethyl) methylammonium salts as buffers for Ga-68-radiolabelling of PSMA-HBED-CC.
Chemistry select. 2019; 4 (43): 12524–12527. DOI: 10.1002/slct.201902588.
Antuganov D., Antuganova Y., Zykova T. et al.
Use of capillary electrophoresis for the determination of impurities in preparations of fluorine-18 labelled PET radiopharmaceuticals.
Journal of pharmaceutical and biomedical analysis. 2019; 173: 68–74. DOI: 10.1016/j.jpba.2019.05.016.
Antuganov D., Zykov M., Timofeeva K. et al.
Effect of Pyridine Addition on the Efficiency of Copper-Mediated Radiofluorination of Aryl Pinacol Boronates.
2017; 2 (26): 7909–7912. DOI.10.1002/slct.201701628.

Contacts

Konstantin Samochernykh, Head of the Centre
e-mail: samochernykh_ka@almazovcentre.ru