Research Laboratory for the Development of Anticancer Drugs

Head of the Laboratory — Marina Filimonova.

Specialists of the Laboratory

Leading Researcher Lyudmila Shevchenko
Senior Researcher Viktoria Makarchuk
Senior Researcher Valentina Surinova
Junior Researcher Olga Soldatova
Junior Researcher Anna Shitova
Research Assistant Raisa Grekova
Research Assistant Tatyana Zybinova
Research Assistant Lidiya Koval
Research Assistant Marina Ksenofontova

Major publications

Marina V. Filimonova, Victoria M. Makarchuk, Ljudmila I. Shevchenko, Alina S. Saburova, Valentina I. Surinova, Olga S. Izmestieva, Anatoly A. Lychagin, Vyacheslav O. Saburov, Petr V. Shegay, Andrey D. Kaprin, Sergey A. Ivanov, Alexander S. Filimonov / Radioprotective Activity of the Nitric Oxide Synthases Inhibitor T1023. Toxicological and Biochemical Properties, Cardiovascular and Radioprotective Effects // Radiation Research, 2020, принята к публикации 3.08.20.
Saburova A. S., Filimonova M. V., Yuzhakov V. V., Shevchenko L. I., Yakovleva N. D., Bandurko L. N., Koretskaya A. E., Fomina N. K., Saburov V. O., Filimonov A. S. / The influence of nitric oxide synthases inhibitor Т1023 on the development of radiation pneumofibrosis in rats // Radiatsionnaya Gygiena, 2020, 13(1), р. 60-67 DOI: 10.21514/1998-426Х-2020-13-1-60-67
Alexeev A. A., Nurieva E. V., Trofimova T. P., Chesnakova E. A., Grishin Y. K., Lyssenko K. A., Filimonova M. V., Zefirova O. N. / Bicyclic bridged isothioureas: synthesis and evaluation of activity in a model of lipopolysaccharide-induced septic shock // Mendeleev Communications, 2019, 29(1), p. 14-16 DOI: 10.1016/j.mencom.2019.01.003
Nurieva E. V., Trofimova T. P., Alexeev A. A., Proshin A. N., Chesnakova E. A. d., Grishin Y. K., Lyssenko K. A., Filimonova M. V., Bachurin S. O., Zefirova O. N. / Synthesis and antihypotensive properties of 2-amino-2-thiazoline analogues with enhanced lipophilicity // Mendeleev Communications, 2018, 28(4), с. 390-392 DOI: 10.1016/j.mencom.2018.07.016
Filimonova M. V., Podosinnikova T. S., Samsonova A. S., Makarchuk V. M., Shevchenko L. I., Filimonov A. S. / Comparison of Antitumor Effects of Combined and Separate Treatment with NO Synthase Inhibitor T1023 and PDK1 Inhibitor Dichloroacetate // Bulletin of Experimental Biology and Medicine, 2019, 168(1), p. 92-94 DOI: 10.1007/s10517-019-04655-1
Efimenko I. A., Filimonova M. V., Churakov A. V., Ivanova N. A., Erofeeva O. S., Samsonova A. S., Podosinnikova T. S., Filimonov A. S. / First Polynuclear Palladium Compounds [(C5H12NO)(PdCl3)]n and [(C10H16NO)2(Pd2Cl6)] with High Antitumor and Radioprotective Activity // Russian Journal of Coordination Chemistry/Koordinatsionnaya Khimiya, 2020, 46(5), р. 339-349 DOI: 10.1134 / S1070328420040028
Filimonova M. V., Shevchenko L. I., Makarchuk V. M., Chesnakova E. A., Shevchuk A. S., Filimonov A. S., Kryzhanovskii S. A. / Vasopressor Properties of No Synthase Inhibitor T1059. Part II. Hemodynamic Effects on Hypovolemic Disorders // Pharmaceutical Chemistry Journal, 2020, 53(12), р.1113-1117 DOI: 10.1007/s11094-020-02132-y
Makarchuk V. M., Filimonova M. V., Filimonov A. S., Shevchenko L. I., Izmestieva O. S., Saburova A. S. / Lactatemia as a possible pharmacological marker of NOS-inhibitor T1023 induced radioresistance / Radiation and Risk, 2020, 29(1), р. 45-56 DOI: 10.21870 / 0131-3878-2020-29-1-45-56
Filimonova M. V., Evstratova E. S., Makarchuk V. M., Shevchenko L. I., Filimonov A. S., Petin V. G. / Involvement of Recovery Processes in the Effects of Radioprotectors at the Cellular and Organismal Levels // Biology Bulletin, 2019, 46(12),p. 1619-1624 DOI: 10.1134/S1062359019120033
Filimonova M. V., Shevchenko L. I., Makarchuk V. M., Chesnakova E. A., Surinova V. I., Shevchuk A. S., Filimonov A. S., Kryzhanovskii S. A., Shevchenko T. F., Bugrova A. E., Kalamkarov G. R. / Vasopressor Properties of Nitric Oxide Synthase Inhibitor T1059. Part I: Synthesis, Toxicity, NOS-Inhibition Activity, and Hemodynamic Effects Under Normotensive Conditions // Pharmaceutical Chemistry Journal, 2018, 52(4), с. 294-298 DOI: 10.1007/s11094-018-1809-2
Filimonova M. V., Samsonova A. S., Korneeva T. S., Shevchenko L. I., Filimonov A. S. / Study of the ability of a new nitric oxide synthase inhibitor INOS1 to selectively protect the normal tissue in the Ehrlich carcinoma radiotherapy model // Radiation and Risk, 2018, 27(2), с. 37-45 DOI: 10.21870 / 0131-3878-2018-27-2-37-45
Filimonova M. V., Samsonova A. S., Korneeva T. S., Shevchenko L. I., Saburov V. O., Filimonov A. S. / The radioprotective effects of nitric oxide synthase inhibitor T1023 on normal and malignant tissues // Radiation and Risk, 2018, 27(2), с. 37-45 DOI: 10.21870 / 0131-3878-2018-27-4-155-169

Contacts

Marina Filimonova, Head of the Laboratory
e-mail: mari_fil@mail.ru