Research Centre of Unknown, Rare and Genetically Determined Diseases

Head of the Department — Elena Vasichkina.

Structure

Research Department of Unknown, Rare and Genetically Determined Diseases
Research Laboratory of Molecular and Cellular Modeling and Gene Therapy
Research Laboratory of Lipid Metabolism Disorders and Atherosclerosis
Research Laboratory of Excessive Calcification Diseases

Research Group of Molecular Mechanisms of Calcification
Biological Modelling Research Group

Research Laboratory of Neurogenesis and Neurodegenerative Diseases
Research Laboratory of Autoimmune and Autoinflammatory Diseases
Research Group of Hypersomnias and Breathing Disorders
Research Laboratory of Metabolomic and Metabolic Profiling

Major publications

Spatiotemporal structure of cell fate decisions in murine neural crest. Soldatov R., Kaucka M., Kastriti M. E., Petersen J., Chontorotzea T., Englmaier L., Akkuratova N., Yang Y., Häring M., Dyachuk V., Bock C., Farlik M., Piacentino M. L., Boismoreau F., Hilscher M. M., Yokota C., Qian X., Nilsson M., Bronner M. E., Croci L., Hsiao W. Y., Guertin D. A., Brunet J. F., Consalez G. G., Ernfors P., Fried K., Kharchenko P. V., Adameyko I. Science. 2019. DOI: 10.1126/science.aas9536.
Schwann cell precursors contribute to skeletal formation during embryonic development in mice and zebrafish. Xie M., Kamenev D., Kaucka M., Kastriti M. E., Zhou B., Artemov A. V., Storer M., Fried K., Adameyko I., Dyachuk V., Chagin A.S.. Proceedings of the National Academy of Sciences, 2019. DOI: 10.1073/pnas.1900038116
Newton P. T., Li L., Zhou B., Schweingruber C., Hovorakova M., Xie M., Sun X., Sandhow L., Artemov A. V., Ivashkin E., Suter S., Dyachuk V., El Shahawy M., Gritli-Linde A., Bouderlique T., Petersen J., Mollbrink A., Lundeberg J., Enikolopov G., Qian H., Fried K., Kasper M., Hedlund E., Adameyko I., Sävendahl L., Chagin A.S. A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate. Nature. 2019. DOI: 10.1038/s41586-019-0989-6
Soldatov R., Kaucka M., Kastriti M. E., Petersen J., Chontorotzea T., Englmaier L., Akkuratova N., Yang Y., Häring M., Dyachuk V., Bock C., Farlik M., Piacentino M. L., Boismoreau F., Hilscher M. M., Yokota C., Qian X., Nilsson M., Bronner M. E., Croci L., Hsiao W. Y., Guertin D. A., Brunet J. F., Consalez G. G., Ernfors P., Fried K., Kharchenko P. V., Adameyko I. Spatiotemporal structure of cell fate decisions in murine neural crest. Science. 2019. DOI: 10.1126/science.aas9536.
Smolina N., Khudiakov A., Knyazeva A., Zlotina A., Sukhareva K., Kondratov K., Gogvadze V., Zhivotovsky B., Sejersen T., Kostareva A. Desmin mutations result in mitochondrial dysfunction regardless of their aggregation properties. Biochim Biophys Acta Mol Basis Dis. 2020; 24:165745. doi: 10.1016/j.bbadis.2020.165745. IF 4.352
Perepelina K., Klauzen P., Khudiakov A., Zlotina A., Fomicheva Y., Rudenko D., Gordeev M., Sergushichev A., Malashicheva A., Kostareva A. Generation of two iPSC lines (FAMRCi006-A and FAMRCi006-B) from patient with dilated cardiomyopathy and Emery-Dreifuss muscular dystrophy associated with genetic variant LMNAp.Arg527Pro. Stem Cell Res. 2020; 43:101714. doi: 10.1016/j.scr.2020.101714. IF 4.489
Khudiakov A., Perepelina K., Klauzen P., Zlotina A., Gusev K., Kaznacheyeva E., Malashicheva A., Kostareva A. Generation of two iPSC lines (FAMRCi004-A and FAMRCi004-B) from patient with familial progressive cardiac conduction disorder carrying genetic variant DSP p.His1684Arg. Stem Cell Res. 2020; 43:101720. doi: 10.1016/j.scr.2020.101720. IF 4.489
A. Malashicheva, A. Kostina, A. Kostareva, O. Irtyuga, M. Gordeev and V. Uspensky (2020). “Notch signaling in the pathogenesis of thoracic aortic aneurysms: A bridge between embryonic and adult states.” Biochim Biophys Acta Mol Basis Dis 1866(3): 165631. https://doi.org/10.1016/j.bbadis.2019.165631 IF 4,3 Q1
Aquila G., Kostina A., Vieceli Dalla Sega F., Shlyakhto E., Kostareva A., Marracino L., Ferrari R., Rizzo P., Malaschicheva A 2019 The Notch pathway: a novel therapeutic target for cardiovascular diseases? Expert Opin Ther Targets 23:695–710. https://doi.org/10.1080/14728222.2019.1641198 IF 4,6, Q1
Klauzen P., Perepelina K., Khudiakov A., Zlotina A., Fomicheva Y., Pervunina T., Vershinina T., Kostareva A., Malashicheva A. Generation of two induced pluripotent stem cell lines (FAMRCi005-A and FAMRCi005-B) from patient carrying genetic variant LMNA p.Asp357Val. Stem Cell Res. 2020; 43:101719. doi: 10.1016/j.scr.2020.101719. IF 4.489
Olmastroni E., Tragni E., Casula M., Shlyakhto E. V., Konradi A. O., Rotar O. P., Alieva A. S., Boyarinova M. A., Baragetti A., Catapano A. L., Grigore L., Pellegatta F. Epidemiology Of Cardiovascular Risk Factors In Two Population-based Studies // Atherosclerosis, Supplements. 2018. Т. 35. С. e14-e20.

Contacts

Elena Vasichkina, Head of the Department
tel.: +7 (921) 935-18-90
e-mail: Vasichkina_ES@almazovcentre.ru