Research Group of Theranostics
Research Group of Theranostics
Head of Research Group — Daria Ryzhkova, Leading Researcher.
Objectives
To develop methods for radiochemical synthesis and a quality standard for radiopharmaceuticals for the diagnosis and treatment of endocrine disorders and cancers.
Focus areas
Development of methods for radiochemical synthesis and of a quality standard for radiopharmaceuticals based on cyclotron and generator-produced positron-emitting radionuclides as well as isotopes for radionuclide therapy.
Project description
Creating a line of radiopharmaceuticals for determining the radiation phenotype of malignant tumors of various sites in order to personalize antitumor treatment.
Specialists
- Daria Ryzhkova, MD, DSc, Head of Research Group, Chief Researcher
- Mikhail Zykov, PhD in Chemistry, Junior Researcher
Newly developed and implemented technologies
- Improvement of radiochemical synthesis methods and development of a quality standard for radiopharmaceuticals based on [18F] radioisotope: [18F]-fluoromisonidazole ([18F]-MISO) and [18F]-L-dihydroxyphenylalanine ([18F]-DOPA).
- Improvement of the technology for production of [13N]-ammonia.
- Modification of the anion-exchange method for pre-concentration of 68Ga.
- Creation of a novel automatic synthesis module for the production of 68Ga-based radiopharmaceuticals.
- Improvement and implementation of radioisotope techniques:
- PET-CT with 18F-fluorodeoxyglucose to identify inflammatory heart diseases and pituitary microadenomas.
- 18F-DOPA PET/CT for differential diagnosis of diffuse and focal forms of congenital hyperinsulinism, neuroendocrine tumors.
- 13N-ammonia PET/CT at rest and stress in combination with MSCT coronary angiography to assess the functional extent of coronary atherosclerosis, diagnose microvascular cardiac disease and assess the effectiveness of reconstructive cardiovascular surgery.
- 18F-sodium fluoride PET/CT to predict the progression of aortic valve stenosis.
- Contrast-enhanced 18F-FDG PET/CT for differential diagnosis of cardiac tumors.
Patents and inventions
Patent for invention RU 2699218 C1, 03.09.2019. Application No. 2018135814 dated 09.10.2018.
“A method to diagnose MRI-negative ACTH-producing pituitary adenomas”
Authors: Tsoi U. A., Ryzhkova D. V., Cherebillo V. Yu., Dalmatova A. B., Belousova L. V., Kuritsyna N. V., Paltsev A. A., Ryzhkov A. V., Grineva E. N.
Contacts
Daria Ryzhkova, Head of Research Group
e-mail: ryzhkova_dv@almazovcentre.ru
