Research Laboratory of Technologies for Predicting the Risk of Cardiovascular Complications

Head of Laboratory: Alexei Yakovlev, MD, PhD

Major tasks

To conduct basic and applied research aimed at addressing the issues of prevention of cardiovascular and cerebrovascular events in various phenotypic and genotypic groups.
To predict the risk of cardiovascular complications by identifying the prognostic markers for recurrent coronary events in patients with acute coronary syndrome by proteomic, metabolomic and lipidomic analysis.
To develop a protocol for dynamic phenotyping of patients with acute coronary syndrome.
To develop a technology for data profiling of the medical information system, attribute clustering and building correlation pleiades.
To organize and conduct educational events for doctors and patients in order to raise awareness on the key principles and the latest advances in the treatment of patients with acute coronary syndrome.

Focus areas

This project will assess the patterns in the obtained data of proteomic, metabolomic and lipidomic analysis and will perform an in-depth analysis of biomarkers, which in the future can be considered as a tool for predicting the recurrent cardiovascular events in patients after acute coronary syndrome.

Project description

Development of personalized risk prediction programs for cardiovascular pathology based on omics technologies.

Specialists

Alexei Yakovlev MD, PhD, Head of Laboratory
Stanislav Yanishevsky, MD, DSc, Chief Researcher
Yuri Kudaev, Junior Researcher
Tayana Makarova, Research Assistant

International collaboration

In 2018, Almazov Centre and the University of Milan signed a MoU.

Major publications

Metsker O., Magoev K., Yakovlev A., Yanishevskiy S., Kopanitsa G., Kovalchuk S. and Krzhizhanovskaya V.. Identification of risk factors for patients with diabetes: diabetic polyneuropathy case study. BMC Medical Informatics and Decision Making (2020) 20:201 https://doi.org/10.1186/s12911-020-01215-w
Savicheva A., Tapilskaya N., Vorobiev S., Kirichek R., Pirmagomedov R., Rybind M., et al. Secure application of graphene in medicine. GYNECOLOGICAL ENDOCRINOLOGY 2020, VOL. 36, NO. S1, S48–S52 https://doi.org/10.1080/09513590.2020.1816717
Cherniavskiĭ M. A., Zherdev N. N., Chernov A. V., Chernova D. V., Kudaev I. A. Hibrid surgical treatment of an aortic arch aneurysm | Gibridnoe khirurgicheskoe lechenie anevrizmy dugi aorty. Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery, 2019, 25(1), p. 164–167
Zherdev N. N., Chernova D. V., Chernov A. V., Kudaev Y. A., Chernyavskiy M. A Surgical treatment of patient with Gsell-Erdheim syndrome with type a aortic dissection.. Russian Journal of Cardiology, 2019, 24(8), p. 107–110
Gurevich A. 1; Zherdev N. 2; Chernova D. 2; Chernov A. 2; Savello A. 3; Chernyavskiy M. 2; Emelyanov, I. 1; Konradi, A. Orthostatic changes of central blood pressure in hypertensive patients with severe carotid artery stenosis and comorbidities. Journal of Hypertension: July 2019 - Volume 37 - Issue - p e149-e150. doi: 10.1097/01.hjh.0000571920.37250.a1
Chernyavsky M. A., Zherdev N. N., Chernova D. V., Kudaev Y. A., Gusev A. A. A clinical case of hybrid surgical treatment of aortic arch Saccular aneurysm in a patient with newly diagnosed aortic Coarctation. Russian Journal of Cardiology, 2018, 23(11), стр. 130–132.
Chernyavskiy M. A., Artyushin B. S., Chernov A. V., Zherdev N. N., Kudaev, Y. A., Chuikova I. O A clinical case of hybrid treatment of a patient with multilevel arterial occlusive disease in lower limb arteries. Patologiya Krovoobrashcheniya i Kardiokhirurgiya, 2018, 22(4), p. 103–110.

Contacts

Alexey Yakovlev, Head of the Laboratory
e-mail: yakovlev_an@almazovcentre.ru