Research Group of Molecular Mechanisms of Calcification
Research Group of Molecular Mechanisms of Calcification
Head of Group: Anna Malashicheva, PhD in Biology, Senior Researcher.
Objective
To conduct basic research in the field of congenital and acquired diseases of the aorta and aortic valve, systematization with subsequent improvement in the diagnosis and treatment of patients with thoracic aortic diseases.
Tasks
The Research Group acts as a centre for the transfer of new technologies and interaction of the Centre’s research teams with users of research products in order to actively promote the Centre’s developments in the market of intellectual services, high technologies and search for investors.
The Group develops and introduces into clinical practice new technologies and treatment approaches for patients with thoracic aortic diseases, carries out a long-term follow-up of patients after conventional and hybrid surgical procedures.
The Group has a well-defined and consistently implemented scientific program and the key pillar is an interdisciplinary approach to diagnosis, treatment and research.
Specialists
-
Anna Malashicheva, PhD in Biology, Head of Research Group, Senior Researcher
-
Arseny Lobov, PhD in Biology
-
Nadezhda Boyarskaya, Junior Researcher
-
Anastasia Shishkova, Junior Researcher
-
Pavel Dokshin, Junior Researcher
-
Olga Kachanova, Research Assistant
International projects
In 2019, a delegation from the University of Oslo headed by Dean of Medicine Ivar Prydz Gladhaug visited Almazov Centre. Other delegation members were: Vice Dean of Internationalization and Innovation Hilde Nebb, Professors Emeritus Ola Didrik Saugstad and Ingvar Jarle Vaage, professors Kare-Olav Stenslokken and Joel Glover, PhD student Cecilie Revhaug.
Major publications
- Chiarini A., Marconi M., Armato U., Dal Pra I., Onorati F., Faggian G., Pasquali A., Patuzzo C., Pignatti P.F., Trabetti E., Malashicheva A., Irtyega O. Studies on sporadic non-syndromic thoracic aortic aneurysms: II. Alterations of extra-cellular matrix components and focal adhesion proteins. European Journal of Preventive Cardiology. 2018. Т. 25. № S1. С. 51-58. IF 5,864
https://pubmed.ncbi.nlm.nih.gov/29708036/
- Kudryavtseva V., Stankevich K., Bolbasov E., Zhuravlev M., Filimonov V., Remnev G., Tverdokhlebov S., Gudima A., Kibler E., Riabov V., Liu T., Klüter H., Kzhyshkowska J., Zhukov Y., Malashicheva A. Atmospheric pressure plasma assisted immobilization of hyaluronic acid on tissue engineering PLA-based scaffolds and its effect on primary human macrophages. Materials & design. 2017. Т. 127. С. 261-271.IF 5,770
https://www.sciencedirect.com/science/article/pii/S0264127517304367
- Kostina A., Shishkova A., Ignatieva E., Irtyuga O., Bogdanova M., Levchuk K., Golovkin A., Zhiduleva E., Uspenskiy V., Moiseeva O., Kostareva A., Malashicheva A., Faggian G., Vaage J., Rutkovskiy A. Different notch signaling in cells from calcified bicuspid and tricuspid aortic valves. Journal of Molecular and Cellular Cardiology. 2018. Т. 114. С. 211-219. IF 4,960
https://pubmed.ncbi.nlm.nih.gov/29158034/
- Rutkovskiy A., Bogdanova M., Stensløkken K.-O., Sullivan G., Fiane A., Vaage J., Malashicheva A., Kostareva A. Valve interstitial cells: the key to understanding the pathophysiology of heart valve calcification. Journal of the American Heart Association. 2017. Т. 6. № 9. С. e006339. IF 4,605
https://pubmed.ncbi.nlm.nih.gov/28912209/
Contacts
Anna Malashicheva, Head of the Group
e-mail: malashicheva_ab@almazovcentre.ru
