Research Laboratory of Metabolic Diseases and Microbiota

Head of Laboratory: Polina Popova, MD, PhD.


To implement the joint projects to develop personalized microbial therapy for metabolic and immune-dependent diseases, study the microbiota in metabolic disorders and the effect of a new coronavirus infection, diabetes mellitus and their combination on pregnancy outcomes.

Focus areas

  • Participating in the development of new methods for the use of autoprobiotics for the treatment of metabolic and immune-dependent diseases (together with the Institute of Experimental Medicine).

  • Creating models for predicting postprandial glycemic response (based on microbiome, nutrition, genotype, history and anthropometric data) and developing a personalized diet therapy system for the treatment and prevention of type 2 diabetes mellitus.

  • Studying the effect of various components of microbiotic communities on the development of carbohydrate metabolism disorders (prediabetes, type 2 diabetes mellitus and gestational diabetes) and systemic inflammation.

  • Studying the pathogenetic mechanisms of cardiovascular disease in patients with metabolic disorders (including microbiome changes and molecular genetic aspects) and developing methods for their prevention.

  • Studying the factors that determine the mechanisms of interaction between diabetes mellitus and coronavirus infection COVID-19 during pregnancy and affect its adverse outcomes.

Project description

  • In-depth analysis of genotype-phenotype correlations and identifying new potential areas for the prevention of chronic non-communicable diseases of polygenic origin in order to create personalized preventive programs.

  • Personalized microbial therapy as an approach to the management of medical conditions (metabolic syndrome and type 2 diabetes) (jointly with the Institute of Experimental Medicine).


  • Polina Popova, MD, PhD, Head of Laboratory

  • Ekaterina Kolesova, Senior Researcher

  • Maria Kokina, Junior Researcher

  • Anna Anopova, Junior Researcher

  • Artem Isakov, Research Assistant

  • Eleonora Pivsaeva, Research Assistant

Newly developed and implemented technologies

"A method for predicting the effectiveness of treatment improving insulin sensitivity in patients with polycystic ovary syndrome" (Permit to use the new medical technology from the Federal Service for Surveillance in Healthcare FS No. 2010/442 dated 31.12.2010).

Major publications


Polina Popova, Head of the Laboratory