Research Laboratory of Metabolic Diseases and Microbiota

Head of Laboratory: Polina Popova, MD, PhD.

Tasks

To implement the joint projects to develop personalized microbial therapy for metabolic and immune-dependent diseases, study the microbiota in metabolic disorders and the effect of a new coronavirus infection, diabetes mellitus and their combination on pregnancy outcomes.

Focus areas

Participating in the development of new methods for the use of autoprobiotics for the treatment of metabolic and immune-dependent diseases (together with the Institute of Experimental Medicine).
Creating models for predicting postprandial glycemic response (based on microbiome, nutrition, genotype, history and anthropometric data) and developing a personalized diet therapy system for the treatment and prevention of type 2 diabetes mellitus.
Studying the effect of various components of microbiotic communities on the development of carbohydrate metabolism disorders (prediabetes, type 2 diabetes mellitus and gestational diabetes) and systemic inflammation.
Studying the pathogenetic mechanisms of cardiovascular disease in patients with metabolic disorders (including microbiome changes and molecular genetic aspects) and developing methods for their prevention.
Studying the factors that determine the mechanisms of interaction between diabetes mellitus and coronavirus infection COVID-19 during pregnancy and affect its adverse outcomes.

Project description

In-depth analysis of genotype-phenotype correlations and identifying new potential areas for the prevention of chronic non-communicable diseases of polygenic origin in order to create personalized preventive programs.
Personalized microbial therapy as an approach to the management of medical conditions (metabolic syndrome and type 2 diabetes) (jointly with the Institute of Experimental Medicine).

Specialists

Polina Popova, MD, PhD, Head of Laboratory
Ekaterina Kolesova, Senior Researcher
Maria Kokina, Junior Researcher
Anna Anopova, Junior Researcher
Artem Isakov, Research Assistant
Eleonora Pivsaeva, Research Assistant

Newly developed and implemented technologies

"A method for predicting the effectiveness of treatment improving insulin sensitivity in patients with polycystic ovary syndrome" (Permit to use the new medical technology from the Federal Service for Surveillance in Healthcare FS No. 2010/442 dated 31.12.2010).

Major publications

Derakhshan, A., Peeters, R. P., Taylor, P. N., Bliddal, S., Carty, D., Meems, M., Vaidya, B., Chen, L., Knight, B., Ghafoor, F., Popova, P. V., … Korevaar, T. I.M. Association of maternal thyroid function with birth weight: a systematic review and individual-participant data meta-analysis. Lancet Diabetes Endocrinol 2020; 8: 501–10 https://doi.org/10.1016/ S2213-8587(20)30061-9
Kerkhof P.L. Djorai R.B., Maslyanskiy A.L., Kolesova E.P., Konradi A.O., Shlyakhto E.V.. Graphical Description of Left Ventricular Volumetric Characteristics in Selected Chronic Inflammatory Diseases. The FASEB Journal. 2020. 34. 1-1. 10.1096/fasebj.2020.34.s1.05996
P. Popova, E. Tikhonov, Y. Pinto, A. Tkachuk, E. Vasukova, A. Dronova, Y. Bolotko, S. Frishman, E. Pustozerov, T. Pervunina, E. Grineva, O. Koren. The influence of gestational diabetes treatment modalities on gut and saliva microbiome composition. Diabetologia 63, 436 (2020). https://doi.org/10.1007/s00125-020-05221-5
Pustozerov, E.; Tkachuk, A.; Vasukova, E.; Dronova, A.; Shilova, E.; Anopova, A.; Piven, F.; Pervunina, T.; Vasilieva, E.; Grineva, E.; Popova, P. The Role of Glycemic Index and Glycemic Load in the Development of Real-Time Postprandial Glycemic Response Prediction Models for Patients With Gestational Diabetes. Nutrients 2020, 12, 302. doi: 10.3390/nu12020302.
Korevaar, T.I.M., Derakhshan, A., Taylor, P.N., , Meima M, Chen L, Bliddal S, Carty DM, Meems M, Vaidya B, Shields B, Ghafoor F, Popova PV, … Peeters, R.P. Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth: A Systematic Review and Meta-analysis. Obstetrical and Gynecological Survey, 2020, 75(1), с. 10-12
Consortium on Thyroid and Pregnancy—Study Group on Preterm Birth, Korevaar TIM, Derakhshan A, Taylor PN, Meima M, Chen L, Bliddal S, Carty DM, Meems M, Vaidya B, Shields B, Ghafoor F, Popova PV, … Peeters RP. Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth. A Systematic Review and Meta-analysis. JAMA. 2019;322(7):632-641 DOI:10.1001/jama.2019.10931
P. Popova , L. Vasilyeva, A. Tkachuck, M. Puzanov, A. Golovkin , Y. Bolotko, E. Pustozerov, E. Vasilyeva, O. Li, I. Zazerskaya, R. Dmitrieva, A. Kostareva, E. Grineva. A Randomised, Controlled Study of Different Glycaemic Targets during Gestational Diabetes Treatment: Effect on the Level of Adipokines in Cord Blood and ANGPTL4 Expression in Human Umbilical Vein Endothelial Cells. International Journal of Endocrinology 2018, Article ID 6481658, https://doi.org/10.1155/2018/6481658
E. Pustozerov, P. Popova, A. Tkachuk, Y. Bolotko, Z. Yuldashev, E. Grineva. Mobile personalized blood glucose prediction system for patients with gestational diabetes mellitus. JMIR mHealth and uHealth. 2018; 6(1): e6. doi: 10.2196/mhealth.9236.
PopovaP, Vasileva L, TkachuckA, PuzanovM, Bolotko Y, PustozerovE, GerasimovA, ZazerskayaI, LiO, VasilievaE, KostarevaA, DmitrievaR, GrinevaE. Association of tribbles homologue 1 gene expression in human umbilical vein endothelial cells with duration of intrauterine exposure to hyperglycaemia Genet. Res., Camb. (2018), 100, pp. 1–9. © Cambridge University Press 2018 doi:10.1017/S0016672318000010
Rotar O.P., Boyarinova M.A., Moguchaia E.V., Kolesova E.P., Erina A.M., Solntsev V.N., Konradi A.O., Shlyakhto E.V. Subclinical target organ damage in subjects with different components of metabolic syndrome. Clinical and Experimental Hypertension, 2018, 40(5), 421-426
Puzanov MV, Vasilyeva LB, Popova PV, Grineva EN, Dmitrieva RI. New approach to cryopreservation of primary non-cultivated human umbilical vein endothelium in biobanking. Biopreservation and Biobanking. 2018; 16(2):114-119. doi: 10.1089/bio.2017.0086.

Contacts

Polina Popova, Head of the Laboratory
e-mail: popova_pv@almazovcentre.ru