World-Class Research Centre
for Personalized Medicine
2 Akkuratova street, St. Petersburg 197341
Head of Laboratory: Anna Kostareva, MD, DSc.
To implement WCRC-based projects dedicated to deciphering the molecular mechanisms of congenital, rare and understudied human diseases.
The work based on modern technologies of molecular genetic analysis will be carried out using technologies of targeted and whole-exome sequencing, epigenetic profiling, transcriptional analysis, microRNA profile analysis, in-depth chromosome analysis through a microarray hybridization approach. The laboratory will use various cellular and animal models obtained using genome editing technologies and reprogramming methods, in particular, tissue-specific differentiated induced pluripotent cell models and genetically modified D. rerio models.
The laboratory is carrying out three scientific projects:
Using multi-omics data to diagnose rare genetic diseases (project supervisor: Anna Zlotina)
Creating models for genetically determined human diseases using induced pluripotent cells (iPCs) (project supervisor: Anna Kostareva)
Developing approaches to the creation and personalized use of gene therapy drugs for congenital genetic disorders of the neuromuscular and cardiovascular systems (project supervisor: Natalya Smolina)
Anna Kostareva, MD, DSc, Head of Laboratory
Renata Dmitrieva, PhD in Biology, Leading Researcher
Anna Zlotina, PhD in Biology, Senior Researcher
Alexandra Kozyreva, MD, PhD, Senior Researcher
Natalya Smolina, MD, PhD, Senior Researcher
Alexander Khudyakov, PhD in Biology, Senior Researcher
Elena Ignatieva, Researcher
Ksenia Perepelina, Researcher
Alexander Boitsov, Junior Researcher
Sergey Zhuk, Junior Researcher
Anna Churkina, Junior Researcher
Ksenia Sukhareva, Junior Researcher
Yury Vakhrushev, Junior Researcher
Yaroslav Dubrovsky, Research Assistant
Oksana Ivanova, Research Assistant
Margarita Komarova, Research Assistant
Alexey Muravyov, Research Assistant
Elizaveta Sivuschina, Research Assistant
Natalia Rodina, Research Assistant
Next-generation targeted sequencing technologies
Microarray-based comparative genomic hybridization (array CGH)
Genome editing technologies
Functional studies using induced pluripotent stem cells
Patents and inventions
Patent No. 2554056 dated 20.06.2015
"A set of synthetic oligonucleotides for determining the nucleotide sequence of the coding part of the NKX2.5, CFC1, GATA4 genes and identifying mutations associated with orphan monogenic disorders underlying familial forms of congenital heart disease"
Authors: Kostareva A. A., Zlotina A. M., Khodyuchenko T. A., Urusova M. E., Kiselev A. M.
Patent No. 2556832 dated 20.07.2015
"A set of synthetic oligonucleotides for determining the nucleotide sequence of the coding part of the DES gene and identifying mutations associated with desmin-related cardiomyopathies"
Authors: Kostareva A. A., Smolina N. A., Malashicheva A. B., Urusova M. E., Kiselev A. M.
Patent No. 2529947 dated 10.10.2014
"Method for obtaining a smooth muscle cell culture"
Authors: Malashicheva A. B., Kostareva A. A., Zverev D. A., Kostina D. A., Uspensky V. E., Gordeev M. L., Urusova M. E.
Patent No. 2206893 dated 20.06.2003
"Method for diagnosing hypertrophic cardiomyopathy"
Authors: Gudkova A. Ya., Mamaev N. N., Semernin E. N., Rybakova M. G., Kostareva A. A., Shlyakhto E. V.
Anna Kostareva, Head of the Laboratory