Research Laboratory of Neurogenesis and Neurodegenerative Diseases

Head of Laboratory: Vyacheslav Dyachuk, Leading Researcher.

Tasks

To investigate non-canonical mechanisms in nervous system development and study the molecular and genetic basis of the pathogenesis of neurodegenerative diseases.

Main projects

Studying the role of neural crest cells and glial stem cells in the morphogenesis of embryonic tissues in transgenic animal models (Danio rerio, Mus Musculus).
Studying the mechanisms of natural (adaptive) transformation of embryonic stem and pluripotent cells into neurons of various ergicity and glial cells in vivo and in vitro.
Studying the role of glia and neurons of the peripheral nervous system in the occurrence and progression of neurodegenerative diseases as well as in the development of carcinogenesis.

Research areas

Molecular hierarchy of neural crest cells and their involvement in the development of embryonic abnormalities
New potentials of embryonic Schwann cells in the development of cell therapy methods for tissue morphogenesis disorders
Role of mature glial cells in axon regeneration: signaling molecules and receptors
Involvement of Schwann cells in carcinogenesis
Development of the peripheral nervous system and its role in the homeostasis

Projects

Role of embryonic glial cells in the development of peripheral nervous system and neurodegenerative diseases (Russian Science Foundation)
Role of nerve-associated stem cells in developmental cell type specialization (Russian Science Foundation)
Study of the mechanisms of glial cell pluripotency in embryonic, larval development and in adult transgenic Danio rerio (Russian Foundation for Basic Research)
Cellular sources and mechanisms of development of peripheral neurons in bony fish (Russian Foundation for Basic Research)

Specialists

Vyacheslav Dyachuk, PhD in Biology, Head of Laboratory, Leading Researcher
Marina Vasyutina, Researcher
Lada Murashova, Junior Researcher
Nikita Burzak, Junior Researcher
Svetlana Osipova, Junior Researcher
Daria Andreeva, Research Assistant
Antonina Udalina, Research Assistant

International collaboration

Karolinska Universitetssjukhuset (Stockholm, Sweden)

Medical Iniversity of Vienna (Austria)

Major publications

Milichko V., Dyachuk V. Novel glial cell functions: extensive potency, stem cell-like properties, and participation in regeneration and transdifferentiation. Frontiers in Cell and Developmental Biology. 2020. DOI: 10.3389/fcell.2020.00809.
Spatiotemporal structure of cell fate decisions in murine neural crest. Soldatov R., Kaucka M., Kastriti M..E, Petersen J., Chontorotzea T., Englmaier L., Akkuratova N., Yang Y., Häring M., Dyachuk V., Bock C., Farlik M., Piacentino M.L., Boismoreau F., Hilscher M.M., Yokota C., Qian X., Nilsson M., Bronner M.E., Croci L., Hsiao W.Y., Guertin D.A., Brunet J.F., Consalez G.G., Ernfors P., Fried K., Kharchenko P.V., Adameyko I. Science. 2019. DOI: 10.1126/science.aas9536.
Schwann cell precursors contribute to skeletal formation during embryonic development in mice and zebrafish. Xie M., Kamenev D., Kaucka M., Kastriti M.E., Zhou B., Artemov A.V., Storer M., Fried K., Adameyko I., Dyachuk V., Chagin A.S.. Proceedings of the National Academy of Sciences, 2019. DOI: 10.1073/pnas.1900038116
Kastriti M.E., Kameneva P., Kamenev D., Dyachuk V., Furlan A., Hampl M., Memic F., Marklund U., Lallemend F., Hadjab S., Calvo-Enrique L., Ernfors P., Fried K., Adameyko I. Schwann Cell Precursors Generate the Majority of Chromaffin Cells in Zuckerkandl Organ and Some Sympathetic Neurons in Paraganglia. Front Mol Neurosci. 2019. DOI: 10.3389/fnmol.2019.00006
Newton P.T., Li L., Zhou B., Schweingruber C., Hovorakova M., Xie M., Sun X., Sandhow L., Artemov A.V., Ivashkin E., Suter S., Dyachuk V., El Shahawy M., Gritli-Linde A., Bouderlique T., Petersen J., Mollbrink A., Lundeberg J., Enikolopov G., Qian H., Fried K., Kasper M., Hedlund E., Adameyko I., Sävendahl L., Chagin A.S. A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate. Nature. 2019. DOI: 10.1038/s41586-019-0989-6
Soldatov R., Kaucka M., Kastriti M..E, Petersen J., Chontorotzea T., Englmaier L., Akkuratova N., Yang Y., Häring M., Dyachuk V., Bock C., Farlik M., Piacentino M.L., Boismoreau F., Hilscher M.M., Yokota C., Qian X., Nilsson M., Bronner M.E., Croci L., Hsiao W.Y., Guertin D.A., Brunet J.F., Consalez G.G., Ernfors P., Fried K., Kharchenko P.V., Adameyko I. Spatiotemporal structure of cell fate decisions in murine neural crest. Science. 2019. DOI: 10.1126/science.aas9536.
Xie M., Kamenev D., Kaucka M., Kastriti M.E., Zhou B., Artemov A.V., Storer M., Fried K., Adameyko I., Dyachuk V*., Chagin A.S*. Schwann cell precursors contribute to skeletal formation during embryonic development in mice and zebrafish. Proc Natl Acad Sci USA. 2019. DOI: 10.1073/pnas.1900038116
The zebrafish tail immobilization (ZTI) test as a new tool to assess stress-related behavior and a potential screen for drugs affecting despair-like states. Demin K. A., Lakstygal A. M.,Chernysh M. V., Krotova N. A. Taranov A. S., Ilyin N. P., Seredinskaya M. V., Tagawa N., Savva A. K., Mor M. S., Vasyutina M. L., Efimova E. V., Kolesnikova T. O., Gainetdinov R. R., Strekalova T., Amstislavskaya T. G., de Abreu M. S., Kalueff A.V. Journal of Neuroscience Methods, 2020. DOI: 10.1016/j.jneumeth.2020.108637
Dyachuk V., Furlan A., Shahidi M. K., Giovenco M., Kaukua N., Konstantinidou C., Pachnis V., Memic F., Marklund U., Müller T., Birchmeier C., Fried K., Ernfors P., Adameyko I. Neurodevelopment. Parasympathetic neurons originate from nerve-associated peripheral glial progenitors // Science. 2014. Vol. 345, № 6192. P. 82-87.
Kaukua N., Shahidi M. K., Konstantinidou C., Dyachuk V., Kaucka M., Furlan A., An Z., Wang L., Hultman I., Ahrlund-Richter L., Blom H., Brismar H., Lopes N. A., Pachnis V., Suter U., Clevers H., Thesleff I., Sharpe P., Ernfors P., Fried K., Adameyko I. Glial origin of mesenchymal stem cells in a tooth model system // Nature. 2014. Vol. 513, № 7519. P. 551-554.