Research Laboratory of Neuroendocrine Tumors

Head of the Laboratory — Ulyana Tsoi.

Objective

To organize research on the topic "Search for new molecular and genetic markers for prediction of the course of neuroendocrine tumors."

Major tasks

• Searching for prognostic markers of the clinical course (aggressive growth, tumor recurrence after surgical treatment), response to medical therapy of growth hormone- and ACTH-secreting pituitary adenomas and multiple PTG lesions in primary hyperparathyroidism.
• Identifying new candidate genes, whose congenital and somatic mutations can cause PGL/PCC and PTG adenomas, and determining the possibility of predicting the course of these diseases depending on the type of mutation (primarily, predicting the malignant behavior of PGL/PCC and multiple PTG lesions).
• Searching for new imaging methods for ACTH-secreting pituitary adenomas, PGL/PCC and PTG adenomas to determine the possibility of using additional treatment methods.
• Searching for possible targets for antitumor therapy for aggressive somatotropin- and corticotropin-secreting tumors as well as malignant pheochromocytomas.
• Searching for genome and transcriptome markers for differential diagnosis of thyroid neoplasms and for predicting sensitivity and safety during radioiodine therapy.

Focus areas

• Study of molecular and genetic markers of pituitary adenomas.
• Study of molecular and genetic markers of pheochromocytomas/paragangliomas (PGL/PCC).
• Study of molecular and genetic markers of primary hyperparathyroidism with multiple tumors.
• Study of molecular and genetic markers for the differential diagnosis of thyroid neoplasms and safe and effective radioiodine therapy.

Project description 

"Search for new molecular and genetic markers for prediction of the clinical course of neuroendocrine tumors".

The Laboratory comprises: 

• Research Group of Theranostics

Specialists of the Laboratory

• Ulyana Tsoy, MD, PhD, Head of Laboratory

• Prof.  Elena Grineva, MD, DSc, Chief Researcher

• Elena Grishina, Chief Researcher

• Vladimir Ryzhkov, Leading Researcher

• Irina Bure, PhD in Biology, Senior Researcher

• Natalya Denisenko, MD, PhD, Senior Researcher

• Ekaterina Kravchuk, Senior Researcher

• Natalia Kuritsyna, MD, PhD, Senior Researcher

• Natalya Khromova, MD, PhD, Researcher

• Olga Kuznetsova, Junior Researcher

• Karina Pogosyan, Junior Researcher 

Contacts

Ulyana Tsoi, Head of the Laboratory
tel.: +7 (921) 346-54-81 
e-mail: tsoy_ua@almazovcentre.ru