Registry for Atherosclerosis established for the development of digital clinical tools

Atherosclerosis is a systemic disease that affects blood vessels in several basins. The patient often has multiple lesions in different sites – coronary arteries, brachiocephalic arteries, aorta, lower limb arteries. The prognosis and optimal treatment strategy are determined by the whole set of lesions, as well as their morphological features and individual progression rates, which can be assessed by the levels of various biomarkers.

Modern artificial intelligence and machine learning technologies make it possible to predict outcomes and complications, as well as the effectiveness of interventions, based on the analysis of large sets of heterogeneous medical data. The development and clinical testing of prognostic models provides new opportunities to determine the optimal strategy for comprehensive patient treatment, including minimally invasive or hybrid surgical procedures, medical therapy, screening and prevention of the most likely complications. To solve such problems, large sets of detailed and properly collected medical data are required.

Specialists at the Research Laboratory of Cardiovascular Risk Prediction Technologies of the WCRC for Personalized Medicine have created a registry of patients with atherosclerotic cardiovascular disease and lesions of the main and peripheral arteries of various localisations, who underwent open or hybrid surgical treatment. This database contains detailed clinical, laboratory and instrumental data in dynamics, and atherosclerotic plaque material and blood samples from the included patients were sent to the biobank.

Further analysis of the accumulated data will allow researchers to identify predictors of adverse events using machine learning technologies, to develop prognostic models for the differentiated risk assessment of complications in patients with lesions of the main and peripheral arteries, and to determine optimal treatment strategies for the most severe patients with multiple arterial lesions that will provide the best long-term clinical outcomes.

15.09.2023