Platform for genotype-phenotype correlations in COVID-19 patients

Investigating the genetic susceptibility to severe COVID-19 is important for understanding the risks associated with the disease. Taking into account genetic factors that influence disease severity can help identify groups of people at increased risk and take early action to protect them. This research will also help develop personalized approaches to COVID-19 treatment and prevention. Scientific knowledge in this area could significantly improve the control of this virus and reduce its impact on public health.

As part of research into the individual characteristics of the course of a new coronavirus infection, the genotypes of 335 patients hospitalized at the Almazov Centre during the 2020-2021 pandemic were studied at the WCRC for Personalized Medicine. Results of a genome-wide association study (GWAS) were obtained for 128 phenotypes, including indicators of laboratory and instrumental tests during hospitalization. The researchers identified associations between DNA variants and the severity of lung damage and mortality.

The results of all genome-wide studies, as well as cross-phenotypic associations, will soon be available on the Almazov Centre website. Open access to genetic data will be useful for research centres estimating genetic risk and analyzing genomic data, as well as for genetic testing companies. The proposed database will allow the construction of polygenic risk scales and the use of reference data for samples with specific conditions. Risk calculation based on genotype and phenotype, construction of risk calculators based on genomic associations and phenotypic features can be used to identify high-risk patients with severe COVID-19.

28.02.2024